Review Articles on Stem Cells

Review articles posted here are a limited selection of reviews on stem cells.

• 2004
• 2003
• 2002

Side Topic Review Articles

The following review articles may be of interest to stem cell researchers. If you wish to suggest additional reviews on side topics that may be of interest to your colleagues, please send your suggestions to Science Editor Heather Rooke at hrooke@isscr.org.

Charge, S. B., and Rudnicki, M. A. (2004). Cellular and Molecular Regulation of Muscle Regeneration. Physiol Rev 84, 209-238.

Grewal, S. I., and Moazed, D. (2003). Heterochromatin and epigenetic control of gene expression. Science 301, 798-802.

Marx, J. (2003). Cancer research. Mutant stem cells may seed cancer. Science 301, 1308-1310.

Park, T., Yi, S. G., Kang, S. H., Lee, S., Lee, Y. S., and Simon, R. (2003). Evaluation of normalization methods for microarray data. BMC Bioinformatics 4, 33.

2004 Review Articles
Updated January 04, 2004

Ahmad, I., Das, A. V., James, J., Bhattacharya, S., and Zhao, X. (2004). Neural stem cells in the mammalian eye: types and regulation . Semin Cell Dev Biol 15 , 53-62.

Aicher, A., Heeschen, C., and Dimmeler, S. (2004). The role of NOS3 in stem cell mobilization . Trends Mol Med 10 , 421-425.

Al-Hajj, M., Becker, M. W., Wicha, M., Weissman, I., and Clarke, M. F. (2004). Therapeutic implications of cancer stem cells . Curr Opin Genet Dev 14 , 43-47.

Al-Hajj, M., and Clarke, M. F. (2004). Self-renewal and solid tumor stem cells . Oncogene 23 , 7274-7282.

Alvarez-Buylla, A., and Lim, D. A. (2004). For the long run; maintaining germinal niches in the adult brain . Neuron 41 , 683-686.

Atala, A., and Koh, C. J. (2004). Tissue engineering applications of therapeutic cloning . Annu Rev Biomed Eng 6 , 27-40.

Attar, E. C., and Scadden, D. T. (2004). Regulation of hematopoietic stem cell growth . Leukemia 18 , 1760-1768.

Bell, D. R., and Van Zant, G. (2004). Stem cells, aging, and cancer: inevitabilities and outcomes . Oncogene 23 , 7290-7296.

Cai, J., Weiss, M. L., and Rao, M. S. (2004). In search of "stemness" . Exp Hematol 32 , 585-598.

Cerny, J., and Quesenberry, P. J. (2004). Chromatin remodeling and stem cell theory of relativity . J Cell Physiol 201 , 1-16.

Chambers, I., and Smith, A. (2004). Self-renewal of teratocarcinoma and embryonic stem cells . Oncogene 23 , 7150-7160.

Cheng, T. (2004). Cell cycle inhibitors in normal and tumor stem cells . Oncogene 23 , 7256-7266.

Conley, B. J., Young, J. C., Trounson, A. O., and Mollard, R. (2004). Derivation, propagation and differentiation of human embryonic stem cells . Int J Biochem Cell Biol 36 , 555-567.

Coulombel, L. (2004). Identification of hematopoietic stem/progenitor cells: strength and drawbacks of functional assays . Oncogene 23 , 7210-7222.

Davidson, A. J., and Zon, L. I. (2004). The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis . Oncogene 23 , 7233-7246.

Davila, J. C., Cezar, G. G., Thiede, M., Strom, S., Miki, T., and Trosko, J. (2004). Use and Application of Stem Cells in Toxicology . Toxicol Sci 79 , 214-223.

De Bruijn, M. F., and Speck, N. A. (2004). Core-binding factors in hematopoiesis and immune function . Oncogene 23 , 4238-4248.

Ding, S., and Schultz, P. G. (2004). A role for chemistry in stem cell biology . Nat Biotechnol 22 , 833-840.

Drukker, M., and Benvenisty, N. (2004). The immunogenicity of human embryonic stem-derived cells . Trends Biotechnol 22 , 136-141.

Estes, B. T., Gimble, J. M., and Guilak, F. (2004). Mechanical signals as regulators of stem cell fate . Curr Top Dev Biol 60 , 91-126.

Fairchild, P. J., Cartland, S., Nolan, K. F., and Waldmann, H. (2004). Embryonic stem cells and the challenge of transplantation tolerance . Trends Immunol 25 , 465-470.

Faubert, A., Lessard, J., and Sauvageau, G. (2004). Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells? Oncogene 23 , 7247-7255.

Fuchs, E., Tumbar, T., and Guasch, G. (2004). Socializing with the Neighbors: Stem Cells and Their Niche . Cell 116 , 769-778.

Gafni, Y., Turgeman, G., Liebergal, M., Pelled, G., Gazit, Z., and Gazit, D. (2004). Stem cells as vehicles for orthopedic gene therapy . Gene Ther.

Gniadecki, R. (2004). Neoplastic stem cells in cutaneous lymphomas: evidence and clinical implications . Arch Dermatol 140 , 1156-1160.

Goldberg, M., and Smith, A. J. (2004). CELLS AND EXTRACELLULAR MATRICES OF DENTIN AND PULP: A BIOLOGICAL BASIS FOR REPAIR AND TISSUE ENGINEERING . Crit Rev Oral Biol Med 15 , 13-27.

Harrington, L. (2004). Does the reservoir for self-renewal stem from the ends? Oncogene 23 , 7283-7289.

Heasley, L. E., and Petersen, B. E. (2004). Signalling in stem cells . EMBO Rep.

Hoang, T. (2004). The origin of hematopoietic cell type diversity . Oncogene 23 , 7188-7198.

Hsieh, J., and Gage, F. H. (2004). Epigenetic control of neural stem cell fate . Current Opinion in Genetics & Development 14 , 461-469.

Jordan, C. T., and Guzman, M. L. (2004). Mechanisms controlling pathogenesis and survival of leukemic stem cells . Oncogene 23 , 7178-7187.

Karpowicz, P., Cohen, C. B., and Van Der Kooy, D. (2004). It is ethical to transplant human stem cells into nonhuman embryos . Nat Med 10 , 331-335.

Koh, C. J., and Atala, A. (2004). Therapeutic cloning and tissue engineering . Curr Top Dev Biol 60 , 1-15.

Kotton, D. N., Summer, R., and Fine, A. (2004). Lung stem cells: New paradigms . Exp Hematol 32 , 340-343.

Lecuyer, E., and Hoang, T. (2004). SCL: From the origin of hematopoiesis to stem cells and leukemia . Exp Hematol 32 , 11-24.

Lee, M. S., and Makkar, R. R. (2004). Stem-Cell Transplantation in Myocardial Infarction: A Status Report . Ann Intern Med 140 , 729-737.

Lensch, M. W., and Daley, G. Q. (2004). Origins of Mammalian hematopoiesis: in vivo paradigms and in vitro models . Curr Top Dev Biol 60 , 127-196.

Lessard, J., Faubert, A., and Sauvageau, G. (2004). Genetic programs regulating HSC specification, maintenance and expansion . Oncogene 23 , 7199-7209.

Losordo, D. W., and Dimmeler, S. (2004). Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease: Part II: Cell-Based Therapies . Circulation 109 , 2692-2697.

McKeon, F. (2004). p63 and the epithelial stem cell: more than status quo? Genes Dev 18 , 465-469.

McNeish, J. (2004). Embryonic stem cells in drug discovery . Nat Rev Drug Discov 3 , 70-80.

Moon, R. T., Kohn, A. D., De Ferrari, G. V., and Kaykas, A. (2004). WNT and beta-catenin signalling: diseases and therapies . Nat Rev Genet 5 , 691-701.

Moore, K. A. (2004). Recent advances in defining the hematopoietic stem cell niche . Curr Opin Hematol 11 , 107-111.

Morshead, C. M., and van der Kooy, D. (2004). Disguising adult neural stem cells . Curr Opin Neurobiol 14 , 125-131.

Nelson, W. J., and Nusse, R. (2004). Convergence of Wnt, beta-catenin, and cadherin pathways . Science 303 , 1483-1487.

Newsome, P. N., Hussain, M. A., and Theise, N. D. (2004). Hepatic oval cells: helping redefine a paradigm in stem cell biology . Curr Top Dev Biol 61 , 1-28.

Nilsson, S. K., and Simmons, P. J. (2004). Transplantable stem cells: home to specific niches . Curr Opin Hematol 11 , 102-106.

Pardal, R., Clarke, M. F., and Morrison, S. J. (2003). Applying the principles of stem-cell biology to cancer . Nat Rev Cancer 3 , 895-902.

Park, I.-K., Morrison, S. J., and Clarke, M. F. (2004). Bmi1, stem cells, and senescence regulation . J Clin Invest 113 , 175-179.

Pasca di Magliano, M., and Hebrok, M. (2003). Hedgehog signalling in cancer formation and maintenance . Nat Rev Cancer 3 , 903-911.

Pelicci, P. G. (2004). Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? J Clin Invest 113 , 4-7.

Perfetto, S. P., Chattopadhyay, P. K., and Roederer, M. (2004). SEVENTEEN-COLOUR FLOW CYTOMETRY: UNRAVELLING THE IMMUNE SYSTEM . Nat Rev Immunol 4 , 648-655.

Pittenger, M. F., and Martin, B. J. (2004). Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics . Circ Res 95 , 9-20.

Rao, M. (2004). Stem and precursor cells in the nervous system . J Neurotrauma 21 , 415-427.

Rao, R. R., and Stice, S. L. (2004). Gene Expression Profiling of Embryonic Stem Cells Leads to Greater Understanding of Pluripotency and Early Developmental Events . Biol Reprod 71 , 1772-1778.

Rookmaaker, M. B., Verhaar, M. C., Van Zonneveld, A. J., and Rabelink, T. J. (2004). Progenitor cells in the kidney: Biology and therapeutic perspectives . Kidney Int 66 , 518-522.

Rothstein, J., and Snyder, E. (2004). Reality and immortality-neural stem cells for therapies. Nat Biotechnol 22 , 283-285.

Sadlon, T. J., Lewis, I. D., and D'Andrea, R. J. (2004). BMP4: Its Role in Development of the Hematopoietic System and Potential as a Hematopoietic Growth Factor . Stem Cells 22 , 457-474.

Sauvageau, G., Iscove, N. N., and Humphries, R. K. (2004). In vitro and in vivo expansion of hematopoietic stem cells . Oncogene 23 , 7223-7232.

Sharpless, N. E., and DePinho, R. A. (2004). Telomeres, stem cells, senescence, and cancer . J Clin Invest 113 , 160-168.

Singh, S. K., Clarke, I. D., Hide, T., and Dirks, P. B. (2004). Cancer stem cells in nervous system tumors . Oncogene 23 , 7267-7273.

Snyder, E. Y., Daley, G. Q., and Goodell, M. (2004). Taking stock and planning for the next decade: realistic prospects for stem cell therapies for the nervous system . J Neurosci Res 76 , 157-168.

Sorrentino, B. P. (2004). CLINICAL STRATEGIES FOR EXPANSION OF HAEMATOPOIETIC STEM CELLS . Nature Reviews Immunology

Nat Rev Immunol 4 , 878-888.

Stocum, D. L. (2004). Amphibian regeneration and stem cells . Curr Top Microbiol Immunol 280 , 1-70.

Stojkovic, M., Lako, M., Strachan, T., and Murdoch, A. (2004). Derivation, growth and applications of human embryonic stem cells . Reproduction 128 , 259-267.

Svendsen, C., and Langston, J. (2004). Stem cells for Parkinson disease and ALS: replacement or protection? Nat Med 10 , 224-225.

Valk-Lingbeek, M. E., Bruggeman, S. W., and Van Lohuizen, M. (2004). Stem cells and cancer; the polycomb connection . Cell 118 , 409-418.

Wagers, A. J., and Weissman, I. L. (2004). Plasticity of adult stem cells . Cell 116 , 639-648.

Warner, J. K., Wang, J. C., Hope, K. J., Jin, L., and Dick, J. E. (2004). Concepts of human leukemic development . Oncogene 23 , 7164-7177.

West, J. A., and Daley, G. Q. (2004). Human embryonic stem cells . Bone Marrow Transplant 33 , 135.

Weyand, C. M., and Goronzy, J. J. (2004). Stem cell aging and autoimmunity in rheumatoid arthritis . Trends Mol Med 10 , 426-433.

Wolf, D. P., Kuo, H.-C., Pau, K.-Y. F., and Lester, L. (2004). Progress with Non-Human Primate Embryonic Stem Cells . Biol Reprod, biolreprod.104.029413.

Yoder, M. C. (2004). Generation of HSCs in the embryo and assays to detect them . Oncogene 23 , 7161-7163.

Young, H. E. (2004). Existence of reserve quiescent stem cells in adults, from amphibians to humans . Curr Top Microbiol Immunol 280 , 71-109.

Back to top

2003 Review Articles
Updated: April 14, 2004

Alonso, L., and Fuchs, E. (2003). Stem cells of the skin epithelium. PNAS 100, 11830-11835.

Atala, A. (2003). Tissue engineering, stem cells, and cloning for the regeneration of urologic organs. Clin Plast Surg 30, 649-667.

Bailey, A. S., and Fleming, W. H. (2003). Converging roads: evidence for an adult hemangioblast. Exp Hematol 31, 987-993.

Baron, M. H. (2003). Embryonic origins of mammalian hematopoiesis. Exp Hematol 31, 1160-1169.

Bonnet, D. (2003). Biology of human bone marrow stem cells. Clin Exp Med 3, 140-149.

Cossu, G., and Bianco, P. (2003). Mesoangioblasts - vascular progenitors for extravascular mesodermal tissues. Curr Opin Genet Dev 13, 537-542.

Czyz, J., Wiese, C., Rolletschek, A., Blyszczuk, P., Cross, M., and Wobus, A. M. (2003). Potential of embryonic and adult stem cells in vitro. Biol Chem 384, 1391-1409.

Daley, G. Q., Goodell, M. A., and Snyder, E. Y. (2003). Realistic prospects for stem cell therapeutics. Hematology (Am Soc Hematol Educ Program), 398-418.

Dawson, L., Bateman-House, A. S., Mueller Agnew, D., Bok, H., Brock, D. W., Chakravarti, A., Greene, M., King, P. A., O'Brien, S. J., Sachs, D. H., et al. (2003). Safety issues in cell-based intervention trials. Fertil Steril 80, 1077-1085.

Doetsch, F. (2003a). The glial identity of neural stem cells. Nat Neurosci 6, 1127-1134.

Doetsch, F. (2003b). A niche for adult neural stem cells. Curr Opin Genet Dev 13, 543-550.

Donovan, P. J., and de Miguel, M. P. (2003). Turning germ cells into stem cells. Curr Opin Genet Dev 13, 463-471.

Ema, H., and Nakauchi, H. (2003). Self-renewal and lineage restriction of hematopoietic stem cells. Curr Opin Genet Dev 13, 508-512.

Galloway, J. L., and Zon, L. I. (2003). Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo. Curr Top Dev Biol 53, 139-158.

Gambardella, L., and Barrandon, Y. (2003). The multifaceted adult epidermal stem cell. Curr Opin Cell Biol 15, 771-777.

Ginis, I., and Rao, M. S. (2003). Toward cell replacement therapy: promises and caveats. Exp Neurol 184, 61-77.

Goldman, S. (2003). Glia as neural progenitor cells. Trends Neurosci 26, 590-596.

Grompe, M. (2003). The role of bone marrow stem cells in liver regeneration. Semin Liver Dis 23, 363-372.

Gurdon, J. B., and Byrne, J. A. (2003). The first half-century of nuclear transplantation. PNAS 100, 8048-8052.

Gurdon, J. B., Byrne, J. A., and Simonsson, S. (2003). Nuclear reprogramming and stem cell creation. Proc Natl Acad Sci U S A 100 Suppl 1, 11819-11822.

Han, Y. M., Kang, Y. K., Koo, D. B., and Lee, K. K. (2003). Nuclear reprogramming of cloned embryos produced in vitro. Theriogenology 59, 33-44.

Hassink, R. J., Dowell, J. D., Brutel de la Riviere, A., Doevendans, P. A., and Field, L. J. (2003). Stem cell therapy for ischemic heart disease. Trends Mol Med 9, 436-441.

Hedrick, M. H., and Daniels, E. J. (2003). The use of adult stem cells in regenerative medicine. Clin Plast Surg 30, 499-505.

Herzog, E. L., Chai, L., and Krause, D. S. (2003). Plasticity of marrow-derived stem cells. Blood 102, 3483-3493.

Hochedlinger, K., and Jaenisch, R. (2003). Nuclear Transplantation, Embryonic Stem Cells, and the Potential for Cell Therapy. N Engl J Med 349, 275-286.

Horner, P. J., and Palmer, T. D. (2003). New roles for astrocytes: The nightlife of an 'astrocyte'. La vida loca! Trends Neurosci 26, 597-603.

Hoyne, G. F. (2003). Notch signaling in the immune system. J Leukoc Biol 74, 971-981.

Koc, O. N., and Gerson, S. L. (2003). Akt helps stem cells heal the heart. Nat Med 9, 1109-1110.

Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A., and Weissman, I. L. (2003). Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol 21, 759-806.

Kyba, M., and Daley, G. (2003a). Hematopoiesis from embryonic stem cells: lessons from and for ontogeny. Exp Hematol 31, 994-1006.

Kyba, M., and Daley, G. Q. (2003b). Hematopoiesis from embryonic stem cells: lessons from and for ontogeny. Exp Hematol 31, 994-1006.

Laslett, A. L., Filipczyk, A. A., and Pera, M. F. (2003). Characterization and culture of human embryonic stem cells. Trends Cardiovasc Med 13, 295-301.

Le Douarin, N. M., and Dupin, E. (2003). Multipotentiality of the neural crest. Curr Opin Genet Dev 13, 529-536.

Lemischka, I. R., and Moore, K. A. (2003). Stem cells: interactive niches. Nature 425, 778-779. Liberg, D., Smale, S. T., and Merkenschlager, M. (2003). Upstream of ikaros. Trends Immunol 24, 567-570.

Maillard, I., Adler, S. H., and Pear, W. S. (2003). Notch and the immune system. Immunity 19, 781-791.

Nakano, T. (2003). Hematopoietic stem cells: generation and manipulation. Trends Immunol 24, 589-594.

Ohnuma, S., and Harris, W. A. (2003). Neurogenesis and the cell cycle. Neuron 40, 199-208.

Owens, D. M., and Watt, F. M. (2003). Contribution of stem cells and differentiated cells to epidermal tumours. Nat Rev Cancer 3, 444-451.

Passegue, E., Jamieson, C. H. M., Ailles, L. E., and Weissman, I. L. (2003). Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? PNAS 100, 11842-11849.

Pevny, L., and Rao, M. S. (2003). The stem-cell menagerie. Trends Neurosci 26, 351-359.

Prockop, D. J., Gregory, C. A., and Spees, J. L. (2003). One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci U S A 100 Suppl 1, 11917-11923.

Rabbany, S. Y., Heissig, B., Hattori, K., and Rafii, S. (2003). Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization. Trends Mol Med 9, 109-117.

Raff, M. (2003). ADULT STEM CELL PLASTICITY: Fact or Artifact? Annu Rev Cell Dev Biol 19, 1-22.

Rafii, S., and Lyden, D. (2003). Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 9, 702-712.

Rhind, S. M., King, T. J., Harkness, L. M., Bellamy, C., Wallace, W., DeSousa, P., and Wilmut, I. (2003). Cloned lambs--lessons from pathology. Nat Biotechnol 21, 744-745.

Rosenthal, N. (2003). Prometheus's Vulture and the Stem-Cell Promise. N Engl J Med 349, 267-274.

Sancho, E., Batlle, E., and Clevers, H. (2003). Live and let die in the intestinal epithelium. Curr Opin Cell Biol 15, 763-770.

Scadden, D. T. (2003). Stem cells and immune reconstitution in AIDS. Blood Rev 17, 227-231.

Spangrude, G. J. (2003). When is a stem cell really a stem cell? Bone Marrow Transplant 32 Suppl 1, S7-S11.

Strain, A. J., Crosby, H. A., Nijjar, S., Kelly, D. A., and Hubscher, S. G. (2003). Human liver-derived stem cells. Semin Liver Dis 23, 373-384.

Street, C. N., Rajotte, R. V., and Korbutt, G. S. (2003). Stem cells: a promising source of pancreatic islets for transplantation in type 1 diabetes. Curr Top Dev Biol 58, 111-136.

Thorgeirsson, S. S., and Grisham, J. W. (2003). Overview of recent experimental studies on liver stem cells. Semin Liver Dis 23, 303-312.

Unwin, R. D., Gaskell, S. J., Evans, C. A., and Whetton, A. D. (2003). The potential for proteomic definition of stem cell populations. Exp Hematol 31, 1147-1159.

Wakayama, T. (2003). Cloned mice and embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Oncol Res 13, 309-314.

Wells, D. N., Oback, B., and Laible, G. (2003). Cloning livestock: a return to embryonic cells. Trends Biotechnol 21, 428-432.

Welm, B., Behbod, F., Goodell, M. A., and Rosen, J. M. (2003). Isolation and characterization of functional mammary gland stem cells. Cell Prolif 36 Suppl 1, 17-32.

Back to top

2002 Review Articles
Updated April 14, 2004

Bradley, J. A., Bolton, E. M., and Pedersen, R. A. (2002). Stem cell medicine encounters the immune system . Nat Rev Immunol 2, 859-871.

Burdon, T., Smith, A., and Savatier, P. (2002). Signalling, cell cycle and pluripotency in embryonic stem cells . Trends Cell Biol 12, 432-438.

Daley, G. Q. (2002). Prospects for stem cell therapeutics: myths and medicines . Curr Opin Genet Dev 12, 607-613.

Efrat, S. (2002). Cell replacement therapy for type 1 diabetes . Trends Mol Med 8, 334-339.

Eiges, R., and Benvenisty, N. (2002). A molecular view on pluripotent stem cells . FEBS Lett 529, 135-141.

Frisen, J. (2002). Stem cell plasticity? Neuron 35, 415-418.

Hirschi, K. K., and Goodell, M. A. (2002). Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells . Gene Ther 9, 648-652.

Lin, H. (2002). The stem-cell niche theory: lessons from flies . Nat Rev Genet 3, 931-940.

Noel, D., Djouad, F., and Jorgense, C. (2002). Regenerative medicine through mesenchymal stem cells for bone and cartilage repair . Curr Opin Investig Drugs 3, 1000-1004.

Presnell, S. C., Petersen, B., and Heidaran, M. (2002). Stem cells in adult tissues . Semin Cell Dev Biol 13, 369-376.

Tisdale, J. F., and Dunbar, C. E. (2002). Plasticity and hematopoiesis: Circe's transforming potion? Curr Opin Hematol 9, 268-273.

Weissman, I. L. (2002). The road ended up at stem cells . Immunol Rev 185, 159-174.

Back to top

Updated: November 4, 2005