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Stem Cell Briefings

A collection of summaries of peer-reviewed articles on developments in stem cell science.

  • Helping to Provide Better Outcomes for Hematopoietic Stem Cell Transplantations
    Posted July 20, 2010
    Delaney C., Heimfeld S., Brashem-Stein C., Voorhies H., Manger R.L., Bernstein I.D. (2010). Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 16(2), 232-236.

  • iPS Cells Help Provide Insights into the Premature Aging Disease Dyskeratosis Congenita
    Posted July 20, 2010
    Agarwal S., Loh Y.H., McLoughlin E.M., Huang J., Park I.H., Miller J.D., Huo H., Okuka M., Dos Reis R.M., Loewer S., Ng H.H., Keefe D.L., Goldman F.D., Klingelhutz A.J., Liu L., Daley G.Q. (2010) Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 464(7286), 292-296.

  • Hairs in a Dish Give Hope to Damaged Ears
    Posted June 14, 2010
    Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J., and Heller, S. (2010). Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Cell 141, 704-716.


  • Enough Data to Swamp a Dinosaur
    Posted May 27, 2010
    Kidder, B. L., and Palmer, S. (2010). Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res 20, 458-472.


  • iPS cells from a young and abundant source of cells: umbilical cord blood.
    Posted March 30, 2010
    Giorgetti, A., Montserrat, N., Aasen, T., Gonzalez, F., Rodriguez-Piza, I., Vassena, R., Raya, A., Boue, S., Barrero, M. J., Corbella, B. A., et al. (2009). Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2. Cell Stem Cell 5, 353-357.


  • Functional neurons are produced through direct reprogramming of fibroblasts with neuron-specific genes
    Posted March 12, 2010
    Vierbuchen, T, Ostermeier, A, Pang, Z.P., Kokubu, Y, Südhof, T.C., Wernig, M. (2009). Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041.


  • Ageing of the blood—where does the fault lie?
    Posted March 12, 2010
    Mayack, S. R., Shadrach, J. L., Kim, F. S., and Wagers, A. J. (2010). Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature 463, 495-500.


  • Visual Function Rescued in Rats Using Cells Derived From iPS Cells
    Posted February 25, 2010
    Carr, A. J., Vugler, A. A., Hikita, S. T., Lawrence, J. M., Gias, C., Chen, L. L., Buchholz, D. E., Ahmado, A., Semo, M., Smart, M. J., et al. (2009). Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. PLoS One 4, e8152.


  • Resetting the Immune System with Stem Cells to Fight Multiple Sclerosis
    Burt, R. K., Loh, Y., Cohen, B., Stefoski, D., Balabanov, R., Katsamakis, G., Oyama, Y., Russell, E. J., Stern, J., Muraro, P., et al. (2009). Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurol 8, 244-253

  • Danger shown in experimental stem cell therapies—extensive research needed
    Amariglio, N., Hirshberg, A., Scheithauer, B. W., Cohen, Y., Loewenthal, R., Luba Trakhtenbrot, L., Paz, N., Koren-Michowitz, M., Waldman, D., et al. (2009) Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient. PLoS Med 6: e1000029.

  • Reprogramming named Breakthrough of the Year, 2008
    Vogel, G. (2008). Breakthrough of the Year: Reprogramming Cells. Science 322, 1766-1767

  • On the Way to Producing Safer Pluripotent Stem Cells
    Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., Yamanaka, S. (2008). Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science 322, 949-953


  • Direct Cellular Reprogramming Produces Pancreatic Beta Cells
    Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., and Melton, D. A. (2008). In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632.


  • New Tools to Study Disease
    Dimos, J. T., Rodolfa, K. T., Niakan, K. K., Weisenthal, L. M., Mitsumoto, H., Chung, W., Croft, G. F., Saphier, G., Leibel, R., Goland, R., et al. (2008). Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321, 1218-1221.Park, I. H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., and Daley, G. Q. (2008). Disease-specific induced pluripotent stem cells. Cell 134, 877-88


  • Human Embryonic Stem Cells Provide Clues about Fetal Heart Progenitors
    Posted May 28, 2008
    Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., et al. (2008). Human cardiovascular progenitor cells develop from a KDR(+) embryonic-stem-cell-derived population. Nature. doi:10.1038/nature06894.


  • Tissue Engineering to Build a Heart
    Posted April 28, 2008
    Ott, H. C., Matthiesen, T. S., Goh, S. K., Black, L. D., Kren, S. M., Netoff, T. I., and Taylor, D. A. (2008). Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med 14, 213-221.

  • Mice Pave the Way to Insights About Sickle Cell Anemia
    Posted March 21, 2008
    Hanna, J., Wernig, M., Markoulaki, S., Sun, C. W., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L. C., Townes, T. M., Jaenisch, R. (2007). Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318, 1920-1923.


  • Breakthroughs in stem cell biology: Human iPS cells
    Posted February 27, 2008
    Park, I. H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H., Ince, T. A., Lerou, P. H., Lensch, M. W., and Daley, G. Q. (2008). Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451, 141-146.
    Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872.Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917-1920.


  • Peeking at stem cells in the brain
    Posted February 26, 2008
    Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D., Smith, S. D., Wagshul, M. E., Henn, F., Benveniste, H., Djuric, P. M., Enikolopov, G., and Maletic-Savatic, M. (2007). Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 318, 980-985.


  • Nuclear Transfer Skin Cells from Monkey
    Posted February 26, 2008
    Byrne JA, Pedersen DA, Clepper LL, Nelson M, Sanger WG, Gokhale S, Wolf DP, Mitalipov SM (2007). Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature 450, 497-502.


  • Mouse Adult Skin Cells Reprogrammed to Embryonic State
    Posted August 21, 2007
    Maherali, N., et al. (2007). Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1, 55-70
    Okita, K., et al. (2007). Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317.
    Wernig, M., et al. (2007). In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324

Updated July 20, 2010