Stem Cell Science Literature

Literature Highlights

2010 Literature
Click on the month to see the literature highlights from that month or scroll through the list.

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April	May	June
July	August	September

EndNote files

August 10, 2010

Special Focus Issue
Regenerative Medicine, July 2010: Cellular reprogramming and iPS cells

Previews
Loh, K. M., and Lim, B. (2010). Recreating Pluripotency? Cell Stem Cell 7, 137-139.
Commentary on the debate about transcriptional differences—and lack thereof—between ESCs and iPSCs; and a challenge to define best practices for microarray data analysis.

See also: Kim et al., 2010, Nature, doi:10.1038/nature09342 and Polo et al., 2010, Nature Biotech 28, 848-855, demonstrating that iPSCs derived from distinct differentiated cell types show defining transcriptional and epigenetic similarities with their starting cell type.

Ezhkova, E., and Fuchs, E. (2010). Regenerative medicine: An eye to treating blindness. Nature 466, 567-568.
Commentary on Rama et al., 2010, N Engl J Med. 363,147-155

Wagner, W. R., and Griffith, B. P. (2010). Medicine. Reconstructing the lung. Science 329, 520-522.
Commentary on Petersen et al., 2010, Science 329, 539-541 and Ott et al., 2010, Nature Medicine, doi.10.1038.nm.2193. Whole-organ decellularization followed by introduction of regenerating cell populations in a rodent model as a possible strategy for lung regeneration

Review
Mohyeldin, A., Garzon-Muvdi, T., and Quinones-Hinojosa, A. (2010). Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche. Cell Stem Cell 7, 150-161.

Articles
Anand, S., Majeti, B. K., Acevedo, L. M., Murphy, E. A., Mukthavaram, R., Scheppke, L., Huang, M., Shields, D. J., Lindquist, J. N., Lapinski, P. E., et al. (2010). MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med 16, 909-914.

Bai, X., Kim, J., Yang, Z., Jurynec, M. J., Akie, T. E., Lee, J., LeBlanc, J., Sessa, A., Jiang, H., DiBiase, A., et al. (2010). TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell 142, 133-143.

Chen, G., Hou, Z., Gulbranson, D. R., and Thomson, J. A. (2010). Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells. Cell Stem Cell 7, 240-248.

Connelly, J. T., Gautrot, J. E., Trappmann, B., Tan, D. W., Donati, G., Huck, W. T., and Watt, F. M. (2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol 12, 711-718.

Fang, H., Yang, Y., Li, C., Fu, S., Yang, Z., Jin, G., Wang, K., Zhang, J., and Jin, Y. (2010). Transcriptome analysis of early organogenesis in human embryos. Dev Cell 19, 174-184.

Goldstein, A. S., Huang, J., Guo, C., Garraway, I. P., and Witte, O. N. (2010). Identification of a cell of origin for human prostate cancer. Science 329, 568-571.

Hacein-Bey-Abina, S., Hauer, J., Lim, A., Picard, C., Wang, G. P., Berry, C. C., Martinache, C., Rieux-Laucat, F., Latour, S., Belohradsky, B. H., et al. (2010). Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 363, 355-364.

Ieda, M., Fu, J. D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., and Srivastava, D. (2010). Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors. Cell 142, 375-386.

Johnson, R. A., Wright, K. D., Poppleton, H., Mohankumar, K. M., Finkelstein, D., Pounds, S. B., Rand, V., Leary, S. E., White, E., Eden, C., et al. Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466, 632-636.

Kokovay, E., Goderie, S., Wang, Y., Lotz, S., Lin, G., Sun, Y., Roysam, B., Shen, Q., and Temple, S. (2010). Adult SVZ Lineage Cells Home to and Leave the Vascular Niche via Differential Responses to SDF1/CXCR4 Signaling. Cell Stem Cell 7, 163-173.

Milyavsky, M., Gan, O. I., Trottier, M., Komosa, M., Tabach, O., Notta, F., Lechman, E., Hermans, K. G., Eppert, K., Konovalova, Z., et al. (2010). A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal. Cell Stem Cell 7, 186-197.

Mohrin, M., Bourke, E., Alexander, D., Warr, M. R., Barry-Holson, K., Le Beau, M. M., Morrison, C. G., and Passegue, E. (2010). Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis. Cell Stem Cell 7, 174-185.

Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T., and Yamanaka, S. (2010). Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A.

Ohgushi, M., Matsumura, M., Eiraku, M., Murakami, K., Aramaki, T., Nishiyama, A., Muguruma, K., Nakano, T., Suga, H., Ueno, M., et al. (2010). Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells. Cell Stem Cell 7, 225-239.

July 13, 2010

Developmental Biology Community Resource
The Node is a new not-for-profit community Web site for all developmental biologists. At its helm is Eva Amsen, Development's Online Editor and the Node's Community Manager. The Node features an open blog for community members to discuss and debate issues in their field; the up-to-date contents of the top journals in developmental biology; jobs and events; updates and reports on conferences; funding programs; interviews with our editors and authors; as well as other posts of general relevance and interest to the community. Visit The Node: explore, sign up and contribute.

ISSCR Committee Forum
Taylor, P. L., Barker, R. A., Blume, K. G., Cattaneo, E., Colman, A., Deng, H., Edgar, H., Fox, I. J., Gerstle, C., Goldstein, L. S. B.  et al. (2010). Patients Beware: Commercialized Stem Cell Treatments on the Web. Cell Stem Cell 7, 43-49.
ISSCR Task Force on Unproven Stem Cell Therapies Report that lead to the development of the ISSCR-driven educational website 'A Closer Look at Stem Cell Treatments'

Previews
Dirks, P. Cancer stem cells: Invitation to a second round. Nature 466, 40-41.
Commentary on Boiko et al., Nature 466, 40-41. Conflicting observations on whether a distinct subpopulation of tumor cells drives tumour growth and generates cellular variation are discussed.

Polo, J. M. and Hochedlinger, K. (2010). When Fibroblasts MET iPSCs. Cell Stem Cell 7, 5-6.
Commentary on Li et al., 2010, Cell Stem Cell 7, 51-63 and Samavarchi-Tehrani et al., 2010, Cell Stem Cell 7, 64-77. Each suggests that a mesenchymal-to-epithelial transition is a critical initiating event during the derivation of induced pluripotent stem cells (iPSCs) from fibroblasts. In addition, in this month's Cell podcast, Deborah Sweet talks to lead investigators Drs. Pei and Wrana about these findings.

Yamanaka, S. (2010). Patient-Specific Pluripotent Stem Cells Become Even More Accessible. Cell Stem Cell 7, 1-2
Commentary on Seki et al., 2010, Cell Stem Cell 7, 11-14;  Loh et al., 2010, Cell Stem Cell 7, 15-19; and Staerk et al., 2010, Cell Stem Cell 7, 20-24. Each describes the derivation of human iPSCs from peripheral blood.

Articles
Carvajal-Vergara, X., Sevilla, A., D'Souza, S. L., Ang, Y. S., Schaniel, C., Lee, D. F., Yang, L., Kaplan, A. D., Adler, E. D., Rozov, R., et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 465, 808-812.

Kharas, M. G., Lengner, C. J., Al-Shahrour, F., Bullinger, L., Ball, B., Zaidi, S., Morgan, K., Tam, W., Paktinat, M., Okabe, R., et al. (2010). Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med.

Ko, K., Arauzo-Bravo, M. J., Tapia, N., Kim, J., Lin, Q., Bernemann, C., Han, D. W., Gentile, L., Reinhardt, P., Greber, B., et al. Human adult germline stem cells in question. Nature 465, E1; discussion E3.

Mira, H., Andreu, Z., Suh, H., Lie, D. C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortigüela, R., Marqués-Torrejón, M. A., Nakashima, K. et al. (2010). Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus. Cell Stem Cell 7, 78-89.

Rama, P., Matuska, S., Paganoni, G., Spinelli, A., De Luca, M., and Pellegrini, G. (2010). Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration. N Engl J Med. 363,147-155.

Singhal, N., Graumann, J., Wu, G., Arauzo-Bravo, M. J., Han, D. W., Greber, B., Gentile, L., Mann, M., and Scholer, H. R. Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming. Cell 141, 943-955.

Thirabanjasak, D., Tantiwongse, K., and Thorner, P. S. Angiomyeloproliferative lesions following autologous stem cell therapy. J Am Soc Nephrol 21, 1218-1222.

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June 8, 2010

Cell Stem Cell – 3rd Anniversary Issue. This year's anniversary issue includes a review feature on progress towards therapy including Forum articles on funding body efforts in Europe and the U.S. to bridge the gap between basic science and translation, the pharma perspective and a Profile article that covers disagreements about when and how to move to the clinic. A new format type, "In Translation," is launched to focus on promising approaches in the clinical translation of stem cells. This month also sees the debut of online 'Article Collections,' a ready reference point for the wide range of reviews, resource articles and ethics/policy discussions.

ISSCR Committee Forum
Kokovay, E., Ganapathi, M., Morse, R., and Temple, S. (2010). Joanna Wysocka Wins ISSCR Outstanding Young Investigator. Cell Stem Cell 6, 533-534.

Profile
Kathleen M. Wong, K. M. (2010). Elaine Fuchs: ISSCR's President-Elect. Cell Stem Cell 6, 506-507.

Preview: In Translation
Maximilian Diehn, M., and Ravindra Majeti, R. (2010). Metastatic Cancer Stem Cells: An Opportunity for Improving Cancer Treatment? Cell Stem Cell 6, 502-503.

Articles
Buecker, C., Chen, H-H., Polo, J. M., Daheron, L., Bu, L., Barakat, T. S., Okwieka, P., Porter, A., Gribnau, J., Hochedlinger, K., and Geijsen, N. (2010). A Murine ESC-like State Facilitates Transgenesis and Homologous Recombination in Human Pluripotent Stem Cells. Cell Stem Cell 6, 535-546.

Carnevalli, L. S., Masuda, K., Frigerio, F., Le Bacquer, O., Um, S. H., Gandin, V., Topisirovic, I., Sonenberg, N., Thomas, G., and Kozma, S. C. (2010). S6K1 plays a critical role in early adipocyte differentiation. Dev Cell 18, 763-774.

Hanna, J., Cheng, A. W., Saha, K., Kim, J., Lengner, C. J., Soldner, F., Cassady, J. P., Muffat, J., Carey, B. W., and Jaenisch, R. (2010). Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A 107, 9222-9227.

Lengner, C. J., Gimelbrant, A. A., Erwin, J. A., Cheng, A. W., Guenther, M. G., Welstead, G. G., Alagappan, R., Frampton, G. M., Xu, P., Muffat, J., et al. (2010). Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations. Cell 141, 872-883.

Nakamura, S., Kobayashi, K., Nishimura, T., Higashijima, S. I., and Tanaka, M. (2010). Identification of Germline Stem Cells in the Ovary of the Teleost Medaka. Science.

Oshima, K., Shin, K., Diensthuber, M., Peng, A. W., Ricci, A. J., and Heller, S. (2010). Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells. Cell 141, 704-716.

Pang, R., Law, W. L., Chu, A. C. Y., Poon, J. T., Lam, C. S. C., Chow, A. K. M., Ng, L., Cheung, L. W. H., Lan, X. R., Lan, H. Y., et al. (2010). A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer. Cell Stem Cell 6, 603-615.

Roesch, A., Fukunaga-Kalabis, M., Schmidt, E. C., Zabierowski, S. E., Brafford, P. A., Vultur, A., Basu, D., Gimotty, P., Vogt, T., and Herlyn, M. (2010). A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141, 583-594.

Yvan-Charvet, L., Pagler, T., Gautier, E. L., Avagyan, S., Siry, R. L., Han, S., Welch, C. L., Wang, N., Randolph, G. J., Snoeck, H. W., and Tall, A. R. (2010). ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation. Science.

May 11, 2010

ISSCR Executive Note
Witty, N. R. (2010). ISSCR Board of Directors and Officers Election Results. Cell Stem Cell 6, 419-420.

Forum
Müller, F-J., Goldmann, J., Löser, P. and Loring, J. F. (2010). A Call to Standardize Teratoma Assays Used to Define Human Pluripotent Cell Lines. Cell Stem Cell 6, 412-414.

Review
Martino, G., Franklin, R. J., Van Evercooren, A. B., and Kerr, D. A. (2010). Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat Rev Neurol 6, 247-255.

Review of recent literature
Marks, H., Veenstra, G. J. C., and Stunnenberg, H. G. (2010). Insightful Tales from Single Embryonic Cells. Cell Stem Cell 6, 397-398.
Commentary on Guo et al. (2010) Dev Cell 18, 675-685 and Tang et al. (2010) Cell Stem Cell 6, 468-478.

Articles
Asselin-Labat, M. L., Vaillant, F., Sheridan, J. M., Pal, B., Wu, D., Simpson, E. R., Yasuda, H., Smyth, G. K., Martin, T. J., Lindeman, G. J., and Visvader, J. E. (2010). Control of mammary stem cell function by steroid hormone signalling. Nature.

Chen, R., Nishimura, M. C., Bumbaca, S. M., Kharbanda, S., Forrest, W. F., Kasman, I. M., Greve, J. M., Soriano, R. H., Gilmour, L. L., Rivers, C. S., et al. (2010). A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell 17, 362-375.

Ciau-Uitz, A., Pinheiro, P., Gupta, R., Enver, T., and Patient, R. (2010). Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling. Dev Cell 18, 569-578.

Huebsch, N., Arany, P. R., Mao, A. S., Shvartsman, D., Ali, O. A., Bencherif, S. A., Rivera-Feliciano, J., and Mooney, D. J. (2010). Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater.

Lathia, J. D., Gallagher, J., Heddleston, J. M., Wang, J., Eyler, C. E., MacSwords, J., Wu, Q., Vasanji, A., McLendon, R. E., Hjelmeland, A. B., and Rich J. N. (2010). Integrin Alpha 6 Regulates Glioblastoma Stem Cells. Cell Stem Cell 6, 421-432.

Nakagawa, T., Sharma, M., Nabeshima, Y., Braun, R. E., and Yoshida, S. (2010). Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment. Science 328, 62-67.

Skora, A. D., and Spradling, A. C. (2010). Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation. Proc Natl Acad Sci USA 107, 7389-7394.

Stadtfeld, M., Apostolou, E., Akutsu, H., Fukuda, A., Follett, P., Natesan, S., Kono, T., Shioda, T., and Hochedlinger, K. (2010). Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature.

Urbach, A., Bar-Nur, O., Daley, G. Q., and Benvenisty, N. (2010). Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. Cell Stem Cell 6, 407-411.

Vermeulen, L., De Sousa, E. M. F., van der Heijden, M., Cameron, K., de Jong, J. H., Borovski, T., Tuynman, J. B., Todaro, M., Merz, C., Rodermond, H., et al. (2010). Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 12, 468-476.

Wang, H., Noulet, F., Edom-Vovard, F., Le Grand, F., and Duprez, D. (2010). Bmp signaling at the tips of skeletal muscles regulates the number of fetal muscle progenitors and satellite cells during development. Dev Cell 18, 643-654.

Xu, Y., Zhu, X., Hahm, H. S., Wei, W., Hao, E., Hayek, A., and Ding, S. (2010). Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A 107, 8129-8134.

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April 13, 2010

Review Series: Reproductive Biology
The April issue of Journal of Clinical Investigation includes eight reviews that provide an overview on the current understanding of various reproductive processes in model systems and raise questions that need to be addressed if we are to improve human reproductive health, including a review on pre-implantation biology by Cockburn and Rossant.

News and perspectives
Laurance, J. (2010). British boy receives trachea transplant built with his own stem cells. BMJ 340, c1633.

McKnight, K. D., Wang, P., and Kim, S. K. (2010). Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell 6, 300-308.

Articles
Bondar, T., and Medzhitov, R. (2010). p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6, 309-322.

Fasano, C. A., Chambers, S. M., Lee, G., Tomishima, M. J., and Studer, L. (2010). Efficient derivation of functional floor plate tissue from human embryonic stem cells. Cell Stem Cell 6, 336-347.

Himburg, H. A., Muramoto, G. G., Daher, P., Meadows, S. K., Russell, J. L., Doan, P., Chi, J. T., Salter, A. B., Lento, W. E., Reya, T., et al. (2010). Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med 16, 475-482.

Jopling, C., Sleep, E., Raya, M., Marti, M., Raya, A., and Belmonte, J. C. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation.(2010). Nature 464, 606-609.

Nakagawa, T., Sharma, M., Nabeshima, Y., Braun, R. E., and Yoshida, S. (2010). Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment. Science 328, 62-67.

Narva, E., Autio, R., Rahkonen, N., Kong, L., Harrison, N., Kitsberg, D., Borghese, L., Itskovitz-Eldor, J., Rasool, O., Dvorak, P., et al. (2010). High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity. Nat Biotechnol 28, 371-377.

Pardo, M., Lang, B., Yu, L., Prosser, H., Bradley, A., Babu, M. M., and Choudhary, J. (2010). An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 6, 382-395.

Raaijmakers, M. H., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., et al. (2010). Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 464, 852-857.

Steiner, D., Khaner, H., Cohen, M., Even-Ram, S., Gil, Y., Itsykson, P., Turetsky, T., Idelson, M., Aizenman, E., Ram, R., et al. (2010). Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension. Nat Biotechnol 28, 361-364.

van den Berg, D. L., Snoek, T., Mullin, N. P., Yates, A., Bezstarosti, K., Demmers, J., Chambers, I., and Poot, R. A. (2010). An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 6, 369-381.

Vastenhouw, N. L., Zhang, Y., Woods, I. G., Imam, F., Regev, A., Liu, X. S., Rinn, J., and Schier, A. F. (2010). Chromatin signature of embryonic pluripotency is established during genome activation. Nature 464, 922-926.

Wang, Y., Krivtsov, A. V., Sinha, A. U., North, T. E., Goessling, W., Feng, Z., Zon, L. I., and Armstrong, S. A. (2010). The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science 327, 1650-1653.

Zalzman, M., Falco, G., Sharova, L. V., Nishiyama, A., Thomas, M., Lee, S. L., Stagg, C. A., Hoang, H. G., Yang, H. T., Indig, F. E., et al. (2010). Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 464, 858-863.

March 9, 2010

ISSCR Meeting Review

Podhajcer, O. L. and Miriuka, S. (2010). Stem Cell Research in South America Coming of Age.  Cell Stem Cell 6, 209-213.

Special Issues

In Vitro Cellular and Development Biology—Animal

A collection of articles on the derivation and characterization of human embryonic stem cell (hESC) lines from about 15 groups around the world in addition to reports outlining international efforts to compare hESC culture systems, recommend best practices for stem cell banking, and offer collated cell line information in stem cell registries. Currently published online ahead of print. View Journal contents.

Proceedings of the National Academy of Sciences (USA)

Regenerative Medicine Special Feature—and introductory article followed by 12 research covering a diverse approaches to tissue engineering and regenerative medicine currently under investigation. PNAS (2010) 107:3285-3355.

Bone Marrow Transplantation

A supplement publishing abstracts and panel discussions on Haematopoietic Stem Cell Transplantation for Severe Autoimmune Diseases from a meeting in Florence, Italy
19-20 November 2009. Bone Marrow Transplant. (2010) 45, S1-S25

Forum

Pulin Li, P. and Zon, L. I. (2010). Resolving the Controversy about N-Cadherin and Hematopoietic Stem Cells. Cell Stem Cell 6, 199-202.

Report

Ljungman, P., Bregni, M., Brune, M., Cornelissen, J., de Witte, T., Dini, G., Einsele, H., Gaspar, H. B., Gratwohl, A., Passweg, J., et al. Allogeneic and autologous transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe 2009. Bone Marrow Transplant 45, 219-234.

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Reviews

Aguayo-Mazzucato, C., and Bonner-Weir, S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol 6, 139-148.

Tran, T. T., and Kahn, C. R. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol.

Wollert, K. C., and Drexler, H. Cell therapy for the treatment of coronary heart disease: a critical appraisal. Nat Rev Cardiol.

Articles

Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y., and Traver, D. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature 464, 108-111.

Bhutani, N., Brady, J. J., Damian, M., Sacco, A., Corbel, S. Y., and Blau, H. M. (2009). Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 463, 1042-1047.

Boisset, J. C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., and Robin, C. In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464, 116-120.

Challen, G. A, Boles, N. C., Chambers, S. M. Goodell, M. A. (2010). Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1.

Cell Stem Cell 6, 265-278.

Doupe, D. P., Klein, A. M., Simons, B. D., and Jones, P. H. The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell 18, 317-323.

Articles

Greber, B., Wu, G., Bernemann, C., Joo, J. Y., Han, D. W., Ko, K., Tapia, N., Sabour, D., Sterneckert, J., Tesar, P., Schöler, H. R. (2010). Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells. Cell Stem Cell 6, 215-226.

Han, J., Yuan, P., Yang, H., Zhang, J., Soh, B. S., Li, P., Lim, S. L., Cao, S., Tay, J., Orlov, Y. L., et al. Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature 463, 1096-1100.

Hideyuki Oguro, H., Jin Yuan, J., Hitoshi Ichikawa, H., Tomokatsu Ikawa, T., Satoshi Yamazaki, S., Hiroshi Kawamoto, H., Hiromitsu Nakauchi, H., Atsushi Iwama, A. (2010). Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1. Cell Stem Cell 6, 279-286.

Kissa, K., and Herbomel, P. Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature 464, 112-115.

Popp, C., Dean, W., Feng, S., Cokus, S. J., Andrews, S., Pellegrini, M., Jacobsen, S. E., and Reik, W. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 463, 1101-1105.

Si-Tayeb, K., Lemaigre, F. P., and Duncan, S. A. Organogenesis and development of the liver. Dev Cell 18, 175-189.

Youssef, K. K., Van Keymeulen, A., Lapouge, G., Beck, B., Michaux, C., Achouri, Y., Sotiropoulou, P. A., and Blanpain, C. Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol 12, 299-305.

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February 9, 2010

Reviews
Li, L., and Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. Science 327, 542-545.

Voog, J., and Jones, D. L. (2010). Stem Cells and the Niche: A Dynamic Duo. Cell Stem Cell 6, 103-115.

Articles
Charles, N., Ozawa, T., Squatrito, M., Bleau, A-M., Brennan, C. W., Hambardzumyan, D., Holland, E. C. (2010). Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells. Cell Stem Cell 6, 141-152.

Delaney, C., Heimfeld, S., Brashem-Stein, C., Voorhies, H., Manger, R. L., and Bernstein, I. D. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 16, 232-236.

Ghosh, Z., Wilson, K. D., Wu, Y., Hu, S., Quertermous, T., and Wu, J. C. Persistent Donor Cell Gene Expression among Human Induced Pluripotent Stem Cells Contributes to Differences with Human Embryonic Stem Cells. PLoS One 5, e8975.

Heng, J. C., Feng, B., Han, J., Jiang, J., Kraus, P., Ng, J. H., Orlov, Y. L., Huss, M., Yang, L., Lufkin, T., et al. (2010). The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells. Cell Stem Cell 6, 167-174.

Ideguchi, M., Palmer, T. D., Recht, L. D., and Weimann, J. M. Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J Neurosci 30, 894-904.

Mayack, S. R., Shadrach, J. L., Kim, F. S., and Wagers, A. J. Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature 463, 495-500.

McCormack, M. P., Young, L. F., Vasudevan, S., de Graaf, C. A., Codrington, R., Rabbitts, T. H., Jane, S. M., and Curtis, D. J. The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal. Science. Doi:10.1126/science.1182378.

Naka, K., Hoshii, T., Muraguchi, T., Tadokoro, Y., Ooshio, T., Kondo, Y., Nakao, S., Motoyama, N., and Hirao, A. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463, 676-680.

Pasini, D., Cloos, P. A., Walfridsson, J., Olsson, L., Bukowski, J. P., Johansen, J. V., Bak, M., Tommerup, N., Rappsilber, J., and Helin, K. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature. Doi:10.1038/nature08788.

Pece, S., Tosoni, D., Confalonieri, S., Mazzarol, G., Vecchi, M., Ronzoni, S., Bernard, L., Viale, G., Pelicci, P. G., and Di Fiore, P. P. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140, 62-73.

Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J. C., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J., Näthke I. S. (2010). Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue. Cell Stem Cell 6, 175-181.

Rowe, H. M., Jakobsson, J., Mesnard, D., Rougemont, J., Reynard, S., Aktas, T., Maillard, P. V., Layard-Liesching, H., Verp, S., Marquis, J., et al. KAP1 controls endogenous retroviruses in embryonic stem cells. Nature 463, 237-240.

Sen, G. L., Reuter, J. A., Webster, D. E., Zhu, L., and Khavari, P. A. DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature 463, 563-567.

Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Sudhof, T. C., and Wernig, M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature. Doi:10.1038/nature08797.

January 12, 2010

Method of the Year 2009: Induced Pluripotency
Nature Methods presents a series of articles that showcase induced pluripotency as a tool for discovery and explore the impact this area promises to have in biological research.
Nature Methods (2010) 7, 1-85.

Review series
The Jan. 2010 issue of Journal Clinical Investigation includes a Reviews Series on the clinical implications of current stem cell research.
J Clin Invest (2010) 120, 8-75.

Discussion articles
Lo, B., Parham, L., Alvarez-Buylla, A., Cedars, M., Conklin, B., Fisher, S., Gates, E., Giudice, L., Halme, D. G., Hershon, W., Kriegstein, A., Kwok, P-Y., Wagner R. (2010). Cloning Mice and Men: Prohibiting the Use of iPS Cells for Human Reproductive Cloning. Cell Stem Cell 6, 16-20.

Hal E. Broxmeyer, H. E. (2010). Will iPS Cells Enhance Therapeutic Applicability of Cord Blood Cells and Banking? Cell Stem Cell 6, 21-24.

Review
Lau, J. F., Anderson, S. A., Adler, E., and Frank, J. A. (2009). Imaging approaches for the study of cell-based cardiac therapies. Nat Rev Cardiol.

Reviews of recent literature:
Kushner, J. A., Weir, G. C., Bonner-Weir, S. (2010). Ductal Origin Hypothesis of Pancreatic Regeneration under Attack. Cell Metabolism 11, 2-3.
Commentary on Solar et al., Developmental Cell 17, 849-860.

Panning, B. (2010). Fine-Tuning Silencing. Cell Stem Cell 6, 3-4.
Commentary on Peng et al., 2009, Cell 139, 1290-1302 and Shen et al., 2009, Cell 139, 1303-1314.

Articles
Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., et al. (2010). Lgr5^+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro. Cell Stem Cell 6, 25-36.

Carro, M. S., Lim, W. K., Alvarez, M. J., Bollo, R. J., Zhao, X., Snyder, E. Y., Sulman, E. P., Anne, S. L., Doetsch, F., Colman, H., et al. (2009). The transcriptional network for mesenchymal transformation of brain tumours. Nature.

Chen, D., Pacal, M., Wenzel, P., Knoepfler, P. S., Leone, G., and Bremner, R. (2009). Division and apoptosis of E2f-deficient retinal progenitors. Nature 462, 925-929.

Chng, Z., Teo, A., Pedersen, R. A., Vallier, L. (2010). SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells.Cell Stem Cell 6, 59-70.

Chong, J. L., Wenzel, P. L., Saenz-Robles, M. T., Nair, V., Ferrey, A., Hagan, J. P., Gomez, Y. M., Sharma, N., Chen, H. Z., Ouseph, M., et al. (2009). E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 462, 930-934.

Esteban, M. A., Wang, T., Qin, B., Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., et al. (2010). Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell 6, 71-79.

Falconer, E., Chavez, E. A., Henderson, A., Poon, S. S., McKinney, S., Brown, L., Huntsman, D. G., and Lansdorp, P. M. Identification of sister chromatids by DNA template strand sequences. Nature 463, 93-97.

Lagha, M., Brunelli, S., Messina, G., Cumano, A., Kume, T., Relaix, F., and Buckingham, M. E. (2009). Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell 17, 892-899.

Mathur, D., Bost, A., Driver, I., and Ohlstein, B. A transient niche regulates the specification of Drosophila intestinal stem cells. Science 327, 210-213.

Melton, C., Judson, R. L., and Blelloch, R. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature.

Mosher, J. T., Pemberton, T. J., Harter, K., Wang, C., Buzbas, E. O., Dvorak, P., Simon, C., Morrison, S. J., and Rosenberg, N. A. (2009). Lack of Population Diversity in Human Embryonic Stem-Cell Lines. N Engl J Med.

Pece, S., Tosoni, D., Confalonieri, S., Mazzarol, G., Vecchi, M., Ronzoni, S., Bernard, L., Viale, G., Pelicci, P. G., Di Fiore, P. P. (2010). Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content. Cell 140, 62-73.

Ross, P. J., Suhr, S., Rodriguez, R. M., Chang, E. A., Wang, K., Siripattarapravat, K., Ko, T., and Cibelli, J. B. (2009). Human Induced Pluripotent Stem Cells Produced Under Xeno-Free Conditions. Stem Cells Dev.

Wellner, U., Schubert, J., Burk, U. C., Schmalhofer, O., Zhu, F., Sonntag, A., Waldvogel, B., Vannier, C., Darling, D., zur Hausen, A., et al. (2009). The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11, 1487-1495.

Wurdak, H., Zhu, S., Romero, A., Lorger, M., Watson, J., Chiang, C., Zhang, J., Natu, V. S., Lairson, L. L., Walker, J. R., et al. (2010). An RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation. Cell Stem Cell 6, 37-47.

Zarzeczny, A., Scott, C., Hyun, I., Bennett, J., Chandler, J., Charge, S., Heine, H., Isasi, R., Kato, K., Lovell-Badge, R., et al. (2009). iPS cells: mapping the policy issues.Cell 139, 1032-1037.

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Updated: December 9, 2008